10 Best Retinol Serums 2025, Reviewed by Dermatologists & Editors


“This is my favorite skin care product to date, a bold claim from someone who tests beauty products for a living,” says Glamour beauty contributor Denise Primbet. Ever since Medik8 put retinaldehyde on the map—the type of a retinoid that’s more gentle on the skin and acts 11x faster than traditional retinol—the Crystal Retinal has been clinically proven to visibly reduce the appearance of wrinkles, brighten stubborn dark spots and help plump up your complexion. “What sets this product apart is its unique graded system, which includes 6 different concentrations of retinal ranging from 1 (0.01%) for sensitive skin to 24 (0.24%) for expert users, allowing you to choose the right concentration based on your skin’s needs with an online quiz to help you determine your skin type,” says board-certified dermatologist Angela Brimhall.

Denise also praises the formula’s ability to help with acne: “As a 26-year-old, I’m not prioritizing youth-boosting skin care as of yet, though I have my fair share of skin concerns. A few months ago, my skin suffered through yet another PCOS-related acne breakout that was nearly impossible to control. After using the Medik8 Crystal Retinal consistently for 12 weeks, my skin texture and inflammation improved to the point that that I can’t even remember where the acne was in the first place,” she shares.

Best for Mature Skin: Paula’s Choice Clinical 0.3% Retinol + 2% Bakuchiol Treatment

Original video by Glamour senior commerce editor Jenifer Calle using Paula’s Choice Clinical 0.3% Retinol + 2% Bakuchiol Treatment

Paula’s Choice Clinical 0.3% Retinol + 2% Bakuchiol Treatment

  • Pros: Delivers great results when it comes to reducing wrinkles and fine lines; feels nourishing on the lips
  • Cons: May not be suitable for eczema-or-psoriasis-prone skin due to the medium retinol potency

If you’re after an effective serum with youth-boosting benefits, board-certified dermatologist Angela Brimhall advises considering Paula’s Choice. “I highly recommend this formula for individuals looking for an effective yet gentle option in their anti-aging regimen. Not only does it help diminish fine lines and hyperpigmentation but also enhances overall skin texture.” Formulated with a moderate-strength retinol concentration, 2% plant-derived bakuchiol, and firming peptides, this potent blend of ingredients is a must for mature skin. This bakuchiol serum will also help promote your skin’s natural collagen production without compromising your skin barrier. It’s nourishing, lightweight and doesn’t feel too greasy on the skin, making it a solid contender in this roundup. Sure, it may not be the cheapest option out there, but trust us when we tell you that this formulation is well worth the investment. Better yet, it’s also free of parabens, vegan, and cruelty-free.

Glamour’s senior commerce editor Jenifer Calle who has combination skin uses this about twice a week. “I’ve only been testing for a month, but I’ve noticed overall smoothness on my skin. I’m in my 30’s so I like having a retinol product in my skin care routine for my ‘11’ lines. It’s very gentle and absorbs very quickly when applying. I haven’t experienced any redness or irritation, but it does have a slight off putting scent to it,” she says.

Best for Acne: Glow Recipe Blackberry Retinol Blemish Serum

Original video by Glamour beauty contributor Denise Primbet

Glow Recipe Blackberry Retinol Blemish Serum

  • Pros: Suitable for sensitive skin; does a superb job at reducing inflammation and reducing the look of acne scars
  • Cons: Not fragrance-free

Leave it to Glow Recipe to bless the skin-care-obsessed folk with one of the best retinoid formulas on the market. Inspired by Korean skin care, the brand has launched yet another hero product that’s specifically formulated to help minimise acne with an innovative list of ingredients. “It contains a triple blend of retinol, retinal, and retinyl ester that may be helpful for those with acne prone skin. The blackberry extract also acts an as antioxidant while the glycerin and ectoin help with hydration of the skin,” shares board-certified dermatologist Angela Brimhall. Apart from its clarifying and healing benefits, this formula also helps plump up your complexion and reduce the look of fine lines and wrinkles all while keeping your skin nice and hydrated. “What I love most about this product is how quickly it absorbs into the skin without forming that overly greasy layer. Unlike most retinoid formulas I’ve tried, the Blackberry Retinol Blemish Serum doesn’t result in any irritation whatsoever. If anything, my skin ended up looking more soothed and hydrated,” says Glamour contributor Denise Primbet.

Best for Oily Skin: La Roche-Posay Retinol B3 Face Serum

Tested and reviewed by Glamour commerce editor Malia Griggs

La Roche-Posay Retinol B3 Face Serum

  • Pros: A good fit for oily skin due to its oil-free formula; effective when it comes to reducing the first signs of aging; hydrating
  • Cons: Not fragrance-free



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